Lox activities in muscle stem cell niche

Dissecting Lox activities in regulating muscle stem cell niche

The muscle stem cells, the satellite cells, are found within a very distinct microenvironment termed the niche. This niche is largely composed of ECM proteins that affect the satellite cells behavior (quiescence, proliferation and differentiation). Our preliminary results suggest that Lox regulates the niche and by that affects the muscle stem cells. We study its roles within the niche with an aim at identifying the interactions between Lox and other stem cell niches.